Diabetic Nephropathy Diabetic Glomerulopathy Renal Interstitial Syndromes

Before the DCCT, a patient with type 1 diabetes had a 30% to 40% likelihood of developing macroproteinuria (>300 mg/ day), which would quickly progress to renal insufficiency and the need for renal dialysis. This process begins with pro-teinuria and increasing BP as early as 10-15 years after diagnosis of type 1 diabetes. In the early 1970s, when repeated studies showed that lowering of BP reduced cardiovascular events, diabetologists began to observe that good BP control, including use of diuretics, prolonged the interval from the onset of proteinuria to renal failure. The first studies of the angiotension-converting enzyme (ACE) inhibitor capto-pril suggested that treatment reduced macroproteinuria in patients with moderate renal insufficiency. Subsequent work in the 1990s indicated that reduced proteinuria impaired nephron loss and preserved renal function. The protein leak into the glomerular space may contribute to the mesangial proliferative reaction, starting a process that may end with nodular glomerulosclerosis.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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