Effectiveness of Early Detection and Intervention

Treating lipid abnormalities in persons with elevated cardiac risk reduces coronary events and mortality (Grundy et al., 2004). The benefits for persons with elevated lipid levels and low cardiac risk are less certain. Although typical initial interventions, lifestyle modifications such as diet and exercise appear to have minimal effect on abnormal lipid levels, and most adults will eventually require drug therapy. The harms of screening are not well defined, but a potential harm is drug treatment of persons who are unlikely to benefit because of low overall cardiac risk (USPSTF, 2008).

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