Generalized Exfoliative Dermatitis

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Exfoliative dermatitis, also known as erythroderma, is an uncommon but serious skin disorder defined as erythema and scale covering over 90% of the body surface area (Fig. 33-34). The four most common causes of erythroderma are psoriasis, AD, cutaneous T-cell lymphoma (CTCL), and drug reactions. More than 60 drugs have been implicated in cases of exfoliative dermatitis; more often allopurinol, beta-lactam antibiotics, antiseizure medications, and sulfa drugs. More than half of patients will have a known underlying skin disease, but in up to 25% an etiology may never be determined and is termed idiopathic erythroderma. The majority of patients are adults over age 40.

The long-term prognosis is good in patients with drug-induced exfoliative dermatitis. The course tends to be remitting and relapsing in idiopathic cases. The prognosis of patients with associated malignancy usually depends on the

Granuloma Annulare CureExfoliative Dermatitis
Figure 33-35 Granuloma annulare. (e Richard P. Usatine.)

resolution occurs within 4 to 6 weeks in most patients, but residual leg pain and ankle edema can persist for weeks.

Figure 33-34 Erythroderma secondary to pustular psoriasis. © Richard P. Usatine.)

outcome of the malignancy. A skin biopsy can help establish the diagnosis when the underlying skin disease is not known. The approach to treatment should include discontinuation of potentially causative medications and a search for any underlying malignancy. Initial evaluation and treatment usually require hospitalization for fluid and electrolyte replacement, temperature modulation, and prevention and treatment of secondary infection.

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Natural Treatments For Psoriasis

Natural Treatments For Psoriasis

Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.

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