Key Points

• Fasting glucose values of at least 200 mg/dL usually indicate significant beta-cell failure comparable to type 1 diabetes. Beta-cell loss in type 2 may still be reversible, however, even after long periods, if gluco/lipotoxicity is successfully treated.

• Hyperglycemia (even at prediabetes levels), dyslipidemia, and hypertension associated with increased abdominal girth are the cardinal signs of metabolic syndrome.

• Somatic symptoms and signs of type 2 diabetes usually take years to develop; the prolonged "latent" phase depends on the severity of hyperglycemia.

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