Key Treatment

Phosphodiesterase-5 inhibitors (sildenafil, tadalafil, vardenafil) are first-line therapy for erectile dysfunction (ED) (Rudkin et al., 2004; Vardi and Nini, 2007) (SOR: A).

Prostaglandin E,, intraurethral or injected into the corpus cavernosum, is second-line treatment of ED (Jaffe et al., 2004) (SOR: A). Vacuum constriction devices may help ED of any cause (Lue et al., 2004) (SOR: B).

Focused group therapy improves erectile function better than no therapy (Melnik et al., 2007) (SOR: A). Off-label use of SSRI antidepressants improves premature ejaculation by prolonging the preorgasmic plateau (Arafa and Shamioul, 2007) (SOR: A).

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