Key Treatment

Treat mild-moderate C. difficile diarrhea with metronidazole (Zar et al., 2007) (SOR: B).

Vancomycin should be administered for severe C. difficile diarrhea (Zar et al., 2007) (SOR: B).

after therapy. For relapse, a repeat course of the original C. difficile treatment should be administered. Patients who have mild to moderate cases without volume depletion or systemic toxicity can be treated as outpatients.

Discussions of the following infections can be found online at www.expertconsult.com:

• Infectious viral hepatitis

• Endocarditis

http://chestjournal.chestpubs.org/content/129/1_suppl

Evidence-based clinical practice guidelines from the American College of Chest Physicians. www.mrw.interscience.wiley.com/cochrane/cochrane_clsysrev_ subjects_fs.html

Comprehensive analyses of evidence related to bronchitis and many other conditions. http://clinicalevidence.bmj.com/ceweb/index.jsp

Evidence-based reviews of the diagnosis and treatment of many common clinical problems. www.mdcalc.com/curb-65-severity-score-community-acquired-pneumonia CURB-65 score calculator to determine the severity of community-acquired pneumonia and need for hospitalization.

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