Key Treatment

Different preparations of iron salts are equally well tolerated and effective in the treatment of iron deficiency anemia. Controlled-release iron preparations have fewer GI side effects but similar discontinuation rates, so they are no more effective (McDiarmid and Johnson, 2002) (SOR: A).

Pneumovax vaccine should be given to patients with sickle cell disease because they tend to undergo auto splenectomy (Nabel, 2009) (SOR: B).

Treatment of a sickle cell crisis consists of rest, hydration, and oral analgesics, such as NSAIDs, antihistamines, and oral morphine (Nabel, 2009) (SOR: B).

In severe cases of sickle cell, allogenic (sibling) bone marrow transplantation results in an 86% event-free survival at 5 years (Bhetia and Walters, 2008) (SOR: B).

High-dose corticosteroid therapy is the treatment of choice for autoimmune hemolytic anemia (Nabel, 2009) (SOR: B).

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