Key Treatment

Women with a family history suggestive of hereditary breast and ovarian cancer (HBOC) syndrome should be offered genetic counseling (USPSTF, 2005) (SOR: A).

Enhanced breast cancer screening with annual mammograms and breast magnetic resonance imaging (MRI) starting at age 25, or 10 years earlier than the age of earliest diagnosis in the family, are recommended for individuals with BRCA mutations (NCCN, 2008; Saslow et al., 2007) (SOR: C).

Prophylactic mastectomy and oophorectomy dramatically reduce the risk of breast and ovarian cancer in HBOC patients (NCCN, 2008) (SOR: B).

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