Fungal: 40% susceptible to empiric antifungals, 5% will be resistant to empiric therapy.

Bacterial: 10% not responding to empiric antimicrobial therapy and usually with cryptic focus.

Unusual pathogens: 5% will be toxoplasmosis (Toxoplasma gondii) reactivation, atypical mycobacterial, TB, fastidious pathogens (Legionella, Mycoplasma, Chlamydophila).

Viral: 5% of causes (HSV, CMV, EBV, HHV-6, VZV, RSV, influenza, parainfluenza).

Other: 10% will be transplant related (e.g., GVHD) following stem cell transplant, 25% will be undefined.

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