Nonhealing Wounds

Patients underlying healing status may be affected by nutritional status and underlying medical conditions such diabetes, cancer, and anemia. Healing may be slowed by smoking as well as age. Surgical repairs with too much tension on skin closure increase the chance of dehiscence and nonheal-ing. In the United States, chronic wounds affect 6.5 million patients. More than $25 billion is spent annually on treatment of chronic wounds, and the burden is rapidly growing because of increasing health care costs, an aging population, and a sharp rise in the incidence of diabetes and obesity worldwide (Sen et al., 2009).

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