Other Causes

Familial Mediterranean fever Fabry's disease Cyclic neutropenia

From Dale DC. The febrile patient. In Goldman L, Ausiello D (eds). Cecil Textbook of Medicine, 22nd ed. Philadelphia, Saunders, 2004, p 1730.

treatment, and use of antibiotics may delay determining a causative infectious agent. The naproxen test (Naprosyn; 375 mg PO every 12 hours for 3 days) is helpful in determining if the fever is secondary to infection or malignancy. A dramatic decrease in the patient's temperature during the test generally indicates a malignant focus, whereas minimal or no response indicates an infectious etiology.

The prognosis of FUO depends on the etiologic category. Undiagnosed FUO has a very favorable outcome. Patients in whom diagnostic investigations fail to identify an etiology should be followed clinically with serial history reviews and physical examinations until the fever resolves or new diagnostic clues are found.

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