Other Medications Used in Alcohol Treatment Anticonvulsants Topiramate

Anticonvulsants likely exert beneficial effects on y-aminobutyric acid (GABA) receptors. Placebo-controlled studies included carbamazepine (Mueller et al., 1997), divalproex (Brady et al., 2002), and topiramate (Johnson et al., 2003), with a multicenter study confirming the efficacy of topiramate and anticonvulsants for treatment of alcohol use disorders (Johnson et al., 2007). Topiramate was shown to decrease (1) drinks/day, (2) drinks/drinking day, (3) drinking days, (4) heavy-drinking days, and (5) GGT levels (Johnson et al., 2007). Side effects of anticon-vulsants include numbness and tingling, metabolic acido-sis, fatigue, dizziness, loss of appetite, nausea, diarrhea, weight loss, and difficulty concentrating, with memory, and in word finding. Suicidal thoughts or actions are infrequently reported, as are renal calculi and acute secondary glaucoma (Kranzler et al., 2009).

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