Risk Factors

Sarcoidosis can be found worldwide, but regional and racial/ ethnic variations in epidemiology and clinical manifestations are intriguing. For example, it affects persons of Scandinavian origin and African Americans at much higher rates than other populations, with an incidence of 35.5 per 100,000 in African Americans and a slight female predominance. Several occupational and environmental exposures have been studied as possible risk factors for sarcoidosis, but none has been conclusively identified. Genetic susceptibility has also been difficult to define. The HLA class II antigens have been most often associated with susceptibility and prognosis in sarcoidosis, although not in all subpopulations (ATS/ERS/WASOG, 1999). The Sarcoidosis Genetic Analysis study (SAGA) suggested specific genetic loci related to sarcoidosis susceptibility in African Americans (Gray-McGuire et al., 2006); other studies show promise of characterizing susceptibility loci in a broader range of racial/ethnic groups (Iannuzzi, 2007).

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Curing Eczema Naturally

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