Serotonergic Agents

Most episodes of postwithdrawal depression will remit without specific treatment if abstinence from alcohol is maintained for days or weeks (Brown et al., 1988; Schukit, 1983). Whereas patients with comorbid depression often require pharmacotherapy, and although the SSRIs have a low side effect profile, they can exacerbate the tremor, anxiety, and insomnia in early-recovering alcoholics. Recovering alcoholics with comorbid depression may actually do better with TCAs (Nunes and Levin, 2004).

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