Some sarcoidosis patients may require no treatment, or only intermittent nonsteroidal anti-inflammatory drugs (NSAIDs) for joint and constitutional symptoms. Topical corticosteroids may be effective for anterior uveitis and some skin lesions. Inhaled corticosteroids and bronchodilators are often used when cough is a prominent symptom in patients with pulmonary involvement, but response has been equivocal. Systemic therapy is needed for the majority of patients. Systemic corticosteroids are first-line therapy and, for patients with pulmonary involvement, improve symptoms, pulmonary function, and chest x-ray signs of disease.

Second-line therapies include cytotoxic agents and other immunomodulating agents (Baughman et al., 2008). Meth-otrexate and hydroxychloroquine can be used as steroid-sparing agents. In patients with cardiac or neural sarcoidosis, treatment regimens that include cytotoxic therapy (e.g., cyclo-phosphamide) are needed. Other treatment strategies include agents that inhibit tumor necrosis factor alpha (infliximab, adalimumab, etanercept) (Nunes et al., 2005). Comorbid illnesses and multiorgan involvement are common in sarcoid-osis (Cox et al., 2004; Westney et al., 2007), so health-related quality-of-life instruments should be used to monitor global response to therapy (DeVries and Drent, 2007), and multidis-ciplinary team-based care is recommended.

Soccer Fitness 101

Soccer Fitness 101

Be a star on the field in no time! Get Fit For The Soccer Field In 10 Easy Steps! With soccer season looming just around the corner it’s never too early to start getting ready. Soccer is an intense game, and it’s going to take a lot of work on your part to make sure that you’re ready to stay ahead of your competition out on that field.

Get My Free Ebook

Post a comment