Commercial Antioxidants

Several beverages, such as pomegranate juice, red wine, blueberry juice, cranberry juice, orange juice, and green tea, have been touted to have roles in improving erectile function in disease states via their ROS scavenging capacities. In animal models of arteriogenic ED, pomegranate juice decreased oxidative stress and improved, although it did not normalize, erectile function [171, 172]. This beneficial effect of pomegranate juice may be due to its main active ingredients such as polyphenol antioxidants. The other natural polyphenol, resveratrol, found mostly in grapes and red wine, restores penile function in animal models of hypercholesterolemia [173]- and diabetes [174]-induced ED. Cardiovascular protective effects of resvera-trol have been attributed to activation of eNOS and the improvement of endothelial function [175]. However, the exact role and mechanism of action of these commercial antioxidants on oxidative stress in the penis and erectile function await further basic science and clinical investigations.

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