Contents

Part I Basic Research

1 Electromagnetic Radiation and Oxidative Stress in the Male Germ Line 3

Geoffry N. De Iuliis, Bruce V. King, and R. John Aitken

2 Mitochondria as a Source of ROS

in Mammalian Spermatozoa 21

Adam John Koppers

3 Cryostorage and Oxidative Stress in Mammalian Spermatozoa 41

Stuart A. Meyers

4 Sperm Capacitation as an Oxidative Event 57

Eve de Lamirande and Cristian O'Flaherty

5 Protection of Epididymal Spermatozoa from Oxidative Stress 95

6 Lipid Peroxidation in Human Spermatozoa 119

Juan G. Alvarez and R. John Aitken

7 Age and Oxidative Stress in the Germ Line 131

Bernard Robaire, Catriona Paul, and Johanna Selvaratnam

8 Heat and Oxidative Stress in the Germ Line 149

Koji Shiraishi

9 Cytokines and Oxidative Stress in the Germ Line 179

Monika Fraczek, Anna Czernikiewicz, and Maciej Kurpisz

10 Metabolic Strategy in Mammalian Spermatozoa and Oxidative Stress 207

Juan G. Alvarez

11 Role of Protamine Disulphide Cross-Linking in Counteracting Oxidative Damage to DNA 221

Juan G. Alvarez and Jaime Gosalvez

12 Role of Caspase, PARP, and Oxidative Stress in Male Infertility 237

Tamer M. Said and Fariba Khosravi

Part II Clinical Practice

13 Methods for the Detection of ROS in Human

Sperm Samples 257

David Benjamin, Rakesh K. Sharma, Arozia Moazzam, and Ashok Agarwal

14 Direct Methods for the Detection of Reactive

Oxygen Species in Human Semen Samples 275

R. John Aitken, Geoffry N. De Iuliis, and Mark A. Baker

15 ROS and Semen Quality 301

Ralf Henkel

16 Oxidative Stress and Male Infertility: A Clinical Perspective 325

Kelton Tremellen

17 Oxidative Stress and Testicular Torsion 355

Dikmen Dokmeci

18 Varicocele and Oxidative Stress 399

Armand Zini and Naif Al-hathal

19 Recreational Drugs and ROS Production in Mammalian Spermatozoa 417

Fabio Firmbach Pasqualotto and Eleonora Bedin Pasqualotto

20 Oxidative Stress, DNA Damage, and Apoptosis in Male Infertility 433

Tamer M. Said, Constanze Fischer-Hammadeh, Mohammed Hamad, Khaled Refaat, and Mohamad Hammadeh

21 Effect of Oxidative Stress on ART Outcome 449

Mohamad Eid Hammadeh, Mohammed Hamad,

Khaled Refaat, Tamer Said, and Constanze Fischer-Hammadeh

22 Oxidative Stress and the Use of Antioxidants for Idiopathic OATs 485

Ashok Agarwal, Anthony H. Kashou, and Lucky H. Sekhon

23 Leukocytospermia and Oxidative Stress 517

Margot Flint, Ashok Agarwal, and Stefan S. du Plessis

24 Clinical Consequences of Oxidative Stress in Male Infertility 535

Tamer M. Said, Sheila R. Gokul, and Ashok Agarwal

25 Oxidative Stress and Infection 551

Enzo Vicari, Sandro La Vignera, and Aldo E. Calogero

26 The Role of Obesity in ROS Generation and Male Infertility 571

Anthony H. Kashou, Stefan S. du Plessis, and Ashok Agarwal

27 Oxidative Stress in Benign Prostate Hyperplasia 591

Murat Savas

28 Role of Oxidative Stress in ED: Unraveling the Molecular Mechanism 617

Biljana Musicki and Arthur L. Burnett

About the Authors 645

Index 649

Pregnancy Guide

Pregnancy Guide

A Beginner's Guide to Healthy Pregnancy. If you suspect, or know, that you are pregnant, we ho pe you have already visited your doctor. Presuming that you have confirmed your suspicions and that this is your first child, or that you wish to take better care of yourself d uring pregnancy than you did during your other pregnancies; you have come to the right place.

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