Detrimental Effects of ROS in Patients with Prostatitis

In patients suffering from prostatitis, a negative association with sperm motility and morphology has repeatedly been shown because this condition is also associated with increased leukocyte infiltration in semen. [109, 110]. Accordingly, significantly increased seminal oxidative stress has been observed in patients with prostatitis categories NIH I, NIH II, NIH IIIA and NIH IV [111, 112]. However, even in prostatitis categories NIH III (chronic abacterial prostatitis) and NIH IIIB (non-inflammatory chronic pelvic pain syndrome), elevated ROS concentrations accompanied by decreased anti-oxidant levels are present in the semen causing oxidative stress irrespective of the presence of leukocytes [113]. This oxidative stress could be triggered by cytokines [26] and is thought to prompt acrosomal dysfunction in terms of significantly reduced inducibility of the acrosome reaction [59], possibly via destabilization of the sperm plasma membrane by LPO.

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Pregnancy Guide

Pregnancy Guide

A Beginner's Guide to Healthy Pregnancy. If you suspect, or know, that you are pregnant, we ho pe you have already visited your doctor. Presuming that you have confirmed your suspicions and that this is your first child, or that you wish to take better care of yourself d uring pregnancy than you did during your other pregnancies; you have come to the right place.

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