Effect of Oxidative Stress on ART Outcome

Mohamad Eid Hammadeh, Mohammed Hamad, Khaled Refaat, Tamer M. Said, and Constanze Fischer-Hammadeh

Abstract Oxidative stress is a condition that causes cellular damage including destruction of all cellular components including lipids, proteins, nucleic acids, and sugars. It affects negatively the quality of oocytes, sperm oocyte interaction, implantation, and early embryo development which influence the success of pregnancy. Many events related to infertility may occur due to OS in the female reproductive tract, such as endometriosis, hydrosalpinx, polycystic ovarian disease, unexplained infertility, and recurrent pregnancy loss.

Oxidative stress may cause retardation in embryo development and growth due to cell-membrane damage, DNA damage, and apoptosis. Poor quality of spermatozoa due to oxidative stress has been correlated with poor fertilization rates, impaired embryo development, and increased rates of pregnancy loss.

There are many strategies that overcome OS in assisted reproductive techniques like ensuring in vitro culture under low oxygen tension, antioxidant culture media

M.E. Hammadeh, DVM, BSc, PhD (*) • C. Fischer-Hammadeh, MD Department of Obstetrics and Gynecology, University of Saarland, Homburg, Saarland, Germany e-mail: [email protected]; [email protected] M. Hamad, PhD

Department of Pharmacology and Bioscience , Petra University, Amman , Jordan e-mail: [email protected]

Department of Obstetrics and Gynecology, Al Azhar University, Assiut , Egypt e-mail: [email protected]

Andrology Laboratory and Reproductive Tissue Bank ,

The Toronto Institute for Reproductive Medicine, 56 Aberfoyle Crescent, Toronto, ON, Canada M8X2W4 e-mail: [email protected]

A. Agarwal et al. (eds.), Studies on Men's Health and Fertility, Oxidative Stress 449

in Applied Basic Research and Clinical Practice, DOI 10.1007/978-1-61779-776-7_21, © Springer Science+Business Media, LLC 2012

supplementation, control of sperm reactive oxygen species production, and reducing sperm-oocyte coincubation time.

Keywords Assisted reproduction technology • Reactive oxygen species • Oxidative stress • Spermatozoa DNA damage • Female infertility • Male infertility

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