Importance of Oxidative Stress and ROS in Male Infertility

Sperm dysfunction is one of the leading causes of infertility. Despite much research, there is limited knowledge about the causes of sperm dysfunction. However, oxidative stress (OS) has been identified as one of the causes of abnormal sperm function. OS refers to the state in which free radicals overwhelm the body's antioxidant capacity [21]; an excess of ROS can have harmful effects on the tissues and organs [9, 10]. ROS has been shown to negatively affect sperm quality and function [22, 23]. For normal male fertility, a fine balance between the generation of ROS and its removal is very important. Excess of ROS also has a negative impact on the pregnancy outcome as well as the assisted reproductive techniques [24, 25]. Moreover, excess ROS can damage DNA in spermatozoa, induce cell apoptosis, and cause lipid peroxidation, which leads to morphological abnormalities, decrease in fertility, and increased sperm membrane permeability [26-28]. It is important to effectively detect the amount of ROS in a semen sample in order to better treat subfertile male patients.

Pregnancy Guide

Pregnancy Guide

A Beginner's Guide to Healthy Pregnancy. If you suspect, or know, that you are pregnant, we ho pe you have already visited your doctor. Presuming that you have confirmed your suspicions and that this is your first child, or that you wish to take better care of yourself d uring pregnancy than you did during your other pregnancies; you have come to the right place.

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