Key Points

• Spermatozoa with damaged membranes found in infertile patients present with an increase in caspase activity.

• Nuclear and mitochondrial abnormalities induce caspase 3 activation during spermiogenesis.

• Higher levels of PARP homologues were detected in infertile men semen compared to fertile men.

• High levels of cPARP have been reported in infertile men.

• Calcium ions have an important role in the pathophysiology of oxidative stress and can play a role in the relationship between oxidative stress and PARP activity.

• Infertile male patients have higher levels of caspases and increased sperm DNA damage by ROS, which shows positive relationship between apoptosis and male factor infertility.

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