Lipid Peroxidation

Lipids are found in the sperm plasma membrane in form of polyunsaturated fatty acids (PUFA). These fatty acids contain double bonds that make them susceptible to attack by free radicals. The initial attack by the hydroxyl radical leads to a series of chemical reactions referred to as lipid peroxidation [7]. Lipid peroxidation results in damage of the axonemal structure, which has consequences related to sperm motility [8]. Lipid peroxidation is considered to be the first step to sperm dysfunction inflicted by ROS, as well as the most important pathologic process that results in the decrease of sperm parameters [9]. Oxidative damage to the sperm lipid membrane also leads to a loss of membrane integrity, and as a result DNA and proteins can become susceptible to damage.

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