Lycopene

Lycopene is a naturally synthesized carotenoid-class molecule commonly found in fruits and vegetables. It is particularly useful in the human redox defense mechanisms against free radicals. Lycopene has been reported to have the highest quenching rate constant with singlet oxygen and to have a higher plasma level than that of beta-carotene [58]. Normally, it is found in high concentrations in the testes and seminal vesicles; however, decreased levels have been demonstrated in men suffering from infertility. Table 22.2 summarizes recent studies pertaining to lycopene intervention for improving sperm parameters.

References Study design Cases Dosage Duration Ages Main outcome

Mohanty et al. [59]

Case-control

50

Lycopene (8 mg/day)

3-month intervention + 12-month follow-up

21-

-50

t Count (70% f \ Concentration (60% f t Motility (54%)a t SMI (46%)a t Morphology (38%)a t Pregnancy (36%)a

Gupta et al. [58]

Case-control

30

Lycopene (4 mg/day)

3-month intervention + follow-up

23-

-45

t Concentration (67%)a t Motility (53%)a t Morphology (40%)a t Pregnancy (20% )a

Mendiola et al. [60]

Case-control

61 (30A; 31B)

Dietary habits and nutrient consumption recorded48; higher intake of lycopene® (p<0.05)

29-

-38

Low intake of lycopeneA is associated with I Concentration I Motility I Morphology

Oborna et al. [61]

Double-blind, placebo-controlled, crossover

44 (18A; 26B)

Lycopene (20 mg/day); Placebo

Lycopene (20 mg/day) followed by placebo4; Placebo followed by lycopene (20 mg/day)B

27-

-38

I sRAGE levels in seminal plasma (p = 0.012)A, (p = 0.008)B

SMI sperm motility index; sRAGE soluble isoforms of receptor for advanced glycation end products "Percent of patients

SMI sperm motility index; sRAGE soluble isoforms of receptor for advanced glycation end products "Percent of patients

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