Neurogenic ED

Neurogenic ED results from defects in neurotransmission of the smooth muscle response of the penis. It may arise due to trauma to nerves of the brain and spinal cord supplying the penis. Neurological conditions include, but are not limited to, Parkinson's disease, Alzheimer's disease, stroke, multiple sclerosis, spinal cord

Fig. 28.2 ED is predominantly a vascular disease. A variety of chronic conditions that involve vascular disorders are associated with impairment of penile vascular function and characterize vasculogenic ED. The major mechanisms underlying vasculogenic ED are reduced endothelial NO bioavailability and increased oxidative stress (ROS)

Fig. 28.2 ED is predominantly a vascular disease. A variety of chronic conditions that involve vascular disorders are associated with impairment of penile vascular function and characterize vasculogenic ED. The major mechanisms underlying vasculogenic ED are reduced endothelial NO bioavailability and increased oxidative stress (ROS)

injury, or injury of cavernous nerves as a consequence of surgeries for cancer of the prostate, bladder, and colon. More commonly, neurogenic ED results from the degeneration and loss of nerves associated with chronic diseases such as diabetes. Although the molecular mechanisms underlying neurogenic ED are not well understood, the principal theories include impaired nNOS function and reduced neuronal NO bioavailability, reduced blood supply to nerve tissue, deficiency of neurohormonal growth factors and neurotrophic support, and increased oxidative stress [15].

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