Oxidative Stress and Male Infertility 2131 Physiologic Role of ROS

ROS generation is mainly due to electron leakage from the mitochondrial membrane [14]. Many research groups showed that male germ cells have the ability to produce ROS at different stages. ROS may have good or harmful effects on sperm quality depending on the level of ROS, their nature, location, and length of exposure [67]. Under physiological conditions, low levels of ROS generated by spermatozoa are required for their acrosomal reaction and capacitation. Moreover, superoxide anion is important for this function [5] .

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