Oxidative Stress and Placenta Abortions

Placental oxidative stress may affect the embryo implantation causing early pregnancy loss [160] . Oxidative stress also may have a role in patients with recurrent abortions with unknown reason [161]. The elevation of leukocytes numbers during pregnancy may result in ROS generation [162], which may modulate expression of cytokine receptors in the placenta, cytotrophoblasts, vascular endothelial cells, and smooth muscle cells [163] . Patients with recurrent abortions were associated with elevated levels of the T-helper cell 1(Th 1) response and glutathione, while GSH depletion leads to the inhibition of TH1-type cytokines [164].

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