Oxidative Stress and Sperm Egg Binding and Fusion

The ability of human spermatozoa to bind to zona pellucida is enhanced by low levels of ROS [112]. Moreover, addition of NO--releasing compounds to capacitating medium increased the number of spermatozoa bound to the hemizona [113] . Also, production of low levels of hydrogen peroxides by spermatozoa plays a role in the signaling events controlling capacitation and sperm-oocytes fusion [109, 114].

On the contrary, studies revealed that elevated ROS concentrations are associated with poor sperm-oocytes fusion, IVF experiment [75], and standard IVF [115,116]. Also, increased generation of lipoperoxidase has been proposed by Aitken et al. [117] asareasonofhighfailurerateof sperm-oocytefusionbioassay [117].

100 Pregnancy Tips

100 Pregnancy Tips

Prior to planning pregnancy, you should learn more about the things involved in getting pregnant. It involves carrying a baby inside you for nine months, caring for a child for a number of years, and many more. Consider these things, so that you can properly assess if you are ready for pregnancy. Get all these very important tips about pregnancy that you need to know.

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