Oxidative Stress and the Endometrium

It has been reported that both ROS and SOD play important roles in the regulation of endometrial function [58, 155-157]. SOD activity decreases in the late secretory phase, while ROS levels increase [156] , The levels of prostaglandin F2 increase towards the late secretory phase, whereas ROS triggers the release of prostaglandin F2 in vitro [158] , Stimulation of the cyclooxygenase enzyme is brought about by ROS via activation of the transcription factor NFKappa p, similar to menstruation mechanism [140]. Moreover, estrogen or progesterone withdrawal results in increased expression of cyclooxygenase-2 (COX-2) mRNA and increased prostaglandin F2a (PGF2a) synthesis in endometrial cells in vitro indicating the role of

ROS-mediated NFkB activation in the endometrium [140]. The oxidative stress was higher in the stroma of thin endometrium '6 mm [159] as demonstrated by Azumaguchi et al. [159] who studied the relationship between implantation rate and endometrium thickness. In addition, expression of progesterone and estrogen receptors was higher, and TGF a expression was significantly lower in thin endo-metrium. Altered regulation of oxidative stress and levels of steroid receptors and TGF a appear to underlie the low implantation rate seen in patients with thin endometrium [156].

Pregnancy Guide

Pregnancy Guide

A Beginner's Guide to Healthy Pregnancy. If you suspect, or know, that you are pregnant, we ho pe you have already visited your doctor. Presuming that you have confirmed your suspicions and that this is your first child, or that you wish to take better care of yourself d uring pregnancy than you did during your other pregnancies; you have come to the right place.

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