1. Aitken RJ, Baker MA. Oxidative stress, sperm survival and fertility control. Mol Cell Endocrinol. 2006;250:66-9.

2. Aitken RJ, De Luliis GN. On the possible origins of DNA damage in human spermatozoa. Mol Hum Reprod. 2010;16:3-13.

3. Aitken RJ, Baker MA, Sawyer D. Oxidative stress in the male germ line and its role in the aetiology of male infertility and genetic disease. Reprod Biomed Online. 2003;7:65-70.

4. Sharma RK, Agarwal A. Role of reactive oxygen species in male infertility. Urology. 1996;48:835-50.

5. Pasqualotto FF, Sobreiro BP, Hallak J, Pasqualotto EB, Lucon AM. Cigarette smoking is related to a decrease in semen volume in a population of fertile men. BJU Int. 2006;97:324-6.

6. Pasqualotto FF, Umezu FM, Salvador M, Borges Jr E, Sobreiro BP, Pasqualotto EB. Effect of cigarette smoking on antioxidant levels and presence of leukocytospermia in infertile men: a prospective study. Fertil Steril. 2008;90:278-83.

7. Saleh RA, Agarwal A, Sharma RK, Nelson DR, Thomas AJ. Effect of cigarette smoking on levels of seminal oxidative stress in infertile men: a prospective study. Fertil Steril. 2002;78:491-9.

8. Aitken RJ, Baker MA. Oxidative stress and male reproductive biology. Reprod Fertil Dev. 2004;16:581-8.

9. Barroso G, Morshedi M, Oehninger S. Analysis of DNA fragmentation, plasma membrane translocation of phosphatidylserine and oxidative stress in human spermatozoa. Hum Reprod. 2000;15:1338-44.

10. Lewis SEM, Agbaje I, Alvarez J. Sperm DNA tests as useful adjuncts to semen analysis. Syst Biol Reprod Med. 2008;54:111-25.

11. Tremellen K. Oxidative stress and male infertility: a clinical perspective. Hum Reprod Update. 2008;14:243-58.

12. Fishel S, Dowell K, Thornton S. Reproductive possibilities for infertile couples: present and future. In: Bentley GR, Mascie-Taylor CGN, editors. Infertility in the modern world. Cambridge, UK: Cambridge University Press; 2000. p. 17-45.

13. Park B, McPartland JM, Glass M. Cannabis, cannabinoids and reproduction. Prostaglandins Leukot Essent Fatty Acids. 2004;70:189-97.

14. Sharpe P, Smith G. Cannabis: time for scientific evaluation of this ancient remedy. Anesth Analg. 2000;90:237-40.

15. Hall W, Solowij N. Adverse effects of cannabis. Lancet. 1998;352:1611-6.

16. Johnston LD, O'Malley PM, Bachman JG. National survey results on drug use from the monitoring the future study, 1975-1995, vol II. College students and young adults (NIH Publication No. 98-4140). Washington, DC: USDHHS; 1997. p. 35-74.

17. Grinspoon L, Bakalar JB. Marijuana: the forbidden medicine, revised and expanded edition. New Haven, CT: Yale University Press; 1997.

18. Ashton H. Pharmacology and effects of cannabis: a brief review. Br J Psychiatry. 2001;178:101-6.

19. ElSohly MA, Ross SA. Quarterly report, NIDA potency monitoring project, report no. 50. Rockville, MD: National Institute on Drug Abuse; 1994.

20. Zimmer L, Morgan JP. Marijuana myths, marijuana facts. New York, NY: Lindesmith Center; 1997. p. 135-41.

21. Burnette-Curley D, Cabral GA. Differential inhibition of RAW264.7 macrophage tumori-cidal activity by D9-tetrahydrocannabinol. Proc Soc Exp Biol Med. 1995;210:64-76.

22. Davies P, Sornberger GC, Huber GL. Effects of experimental marijuana and tobacco smoke inhalation on alveolar macrophages. Lab Invest. 1979;41:220-3.

23. Beals TF, Fligiel SEG, Stuth S, Tashkin DP. Morphological alterations of alveolar macrophages from marijuana smokers. Am Rev Respir Dis. 1989;139:A336 (Abstract).

24. Sherman MP, Campbell LA, Gong Jr H, Roth MD, Tashkin DP. Respiratory burst and micro-bicidal characteristics of pulmonary alveolar macrophages recovered from smokers of marijuana alone, smokers of tobacco alone, smokers of marijuana and tobacco and nonsmokers. Am Rev Respir Dis. 1991;144:1351-6.

25. Gerard C, Mollereau C, Vassart G, Parmentier M. Nucleotide sequence of a human cannabi-noid receptor cDNA. Nucleic Acids Res. 1990;18:7142.

26. Sugiura T, Kondo S, Sukagawa A, Tonegawa T, Nakane S, Yamashita A, et al. Enzymatic synthesis of anandamide, an endogenous cannabinoid receptor ligand, through N-acylphosphatidylethanolamine pathway in testis: involvement of Ca(2+)-dependent transa-cylase and phosphodiesterase activities. Biochem Biophys Res Commun. 1996;218:113-7.

27. Pertwee RG, Joe-Adigwe G, Hawksworth GM. Further evidence for the presence of cannabi-noid CB1 receptors in mouse vas deferens. Eur J Pharmacol. 1996;296:169-72.

28. Chioccarelli T, Cacciola G, Altucci L, Lewis SE, Ricci G, Ledent C, Meccariello R, Fasano S, Pierantoni R, Cobellis G. Cannabinoid receptor 1 influences chromatin remodeling in mouse spermatids by affecting content of transition protein 2 mRNA and histone displacement. Endocrinology. 2010;151(10):5017-29.

29. Cummins JM, Jequier AM, Martin R, Mehmet D, Goldblatt J. Semen levels of mitochondrial DNA deletions in men attending an infertility clinic do not correlate with phenotype. Int J Androl. 1998;21:47-52.

30. Hayakawa M, Hattori K, Sugiyama S, Ozawa T. Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts. Biochem Biophys Res Commun. 1992;189: 979-85.

31. Corral-Debrinski M, Horton T, Lott MT, Shoffner JM, McKee AC, Beal MF, et al. Marked changes in mitochondrial DNA deletion levels in Alzheimer brains. Genomics. 1994; 23:471-6.

Fromenty B, Carrozzo R, Shanske S, Schon EA. High proportions of mtDNA duplications in patients with Kearns-Sayre syndrome occur in the heart. Am J Med Genet. 1997;71:443-52.

Wiseman H, Halliwell B. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J. 1996;313:17-29.

Wei YH, Lu CY, Lee HC, Pang CY, Ma YS. Oxidative damage and mutation to mitochondrial

DNA and age-dependent decline of mitochondrial respiratory function. Ann N Y Acad Sci.


Sarafian TA, Magallanes JAM, Shau H, Tashkin DP, Roth MD. Oxidative stress produced by marijuana smoke. An adverse effect enhanced by cannabinoids. Am J Respir Cell Mol Biol. 1999;20:1286-93.

Wallace KB, Eelss JT, Madeira VMC, Cortopassi G, Jones DP. Mitochondria-mediated cell injury. Fundam Appl Toxicol. 1997;38:23-37.

Repine JE, Bast A, Lankhorst I; The Oxidative Stress Study Group. Oxidative stress in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1997;156:341-57. Bankson DD, Kestin M, Rifai N. Role of free radicals in cancer and atherosclerosis. Clin Lab Med. 1993;13:463-80.

Bashkatova V, Meunier J, Vanin A, Maurice T. Nitric oxide and oxidative stress in the brain of rats exposed in utero to cocaine. Ann N Y Acad Sci. 2006;1074:632-42. Yelian FD, Sacco AG, Ginsburg KA, Doerr PA, Armant DR. The effects of in vitro cocaine exposure on human sperm motility, intracellular calcium, and oocyte penetration. Fertil Steril. 1994;61(5):915-21.

Bracken MB, Eskenazy B, Sachse K, McSharry JE, Hellenbrand K, Leo Summers L. Association of cocaine use with sperm concentration, motility and morphology. Fertil Steril. 1990;53:315-22.

Marinelli D, Gaspari L, Pedotti P, Taioli E. Mini-review of studies on the effect of smoking and drinking habits on semen parameters. Int J Hyg Environ Health. 2004;207:185-92. Swan SH, Elkin EP, Fenster L. The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996. Environ Health Perspect. 2000;108:961-6. Rosenblum ER, Gavaler JS, Van Thiel DH. Lipid peroxidation: a mechanism for alcohol-induced testicular injury. Free Radic Biol Med. 1989;7:569-77.

Nordmann R, Ribiere C, Rouach H. Ethanol-induced induced lipid peroxidation and oxidative stress in extrahepatic tissues. Alcohol. 1990;25:231-7.

Nordmann R. Alcohol and antioxidant systems. Alcohol. 1994;29:513-22.

Soares SR, Melo M. Cigarette smoking and reproductive function. Curr Opin Obstet Gynecol.


Künzle R, Mueller MD, Hänggi W, Birkhäuser MH, Drescher H, Bersinger NA. Semen quality of male smokers and nonsmokers in infertile couples. Fertil Steril. 2003;79:287-91. Gaur DS, Talekar M, Pathak VP. Effect of cigarette smoking on semen quality of infertile men. Singapore Med J. 2007;48:119-23.

Ramlau-Hansen CH, Thulstrup AM, Aggerholm AS, Jensen MS, Toft G, Bonde JP. Is smoking a risk factor for decreased semen quality? A cross-sectional analysis. Hum Reprod. 2007;22:188-96.

Suleiman SA, Elamin Ali M, Zaki EMS, EL-Malik EMA, Nasr MA. Lipid peroxidation and human sperm motility: protective role of Vitamin E. J Androl. 1996;17:530-7. Kumosani TA, Elshal MF, Al-Jonaid AA, Abduljabar HS. The influence of smoking on semen quality, seminal microelements and Ca2+-ATPase activity among infertile and fertile men. Clin Biochem. 2008;41:1199-203.

Thompson J, Bannigan J. Cadmium: toxic effects on the reproductive system and the embryo. Reprod Toxicol. 2008;25:304-15.

Koksal IT, Usta M, Orhan I, Abbasoglu S, Kadioglu A. Potential role of reactive oxygen species on testicular pathology associated with infertility. Asian J Androl. 2003;5:95-9. Arabi M, Mosthaghi H. Influence of cigarette smoking on spermatozoa via seminal plasma. Andrologia. 2005;37:119-24.

56. Sorahan T, Prior P, Lancashire RJ, Faux SP, Hulten MA, Peck IM, Stewart AM. Childhood cancer and parental use of tobacco: deaths from 1971 to 1976. Br J Cancer. 1997;76:1525-31.

57. Yamamoto Y, Isoyama E, Sofikitis N, Miyagawa I. Effects of smoking on testicular function and fertilizing potential in rats. Urol Res. 1998;26:45-8.

58. Rajpurkar A, Jiang Y, Dhabuwala CB, Dunbar JC, Li H. Cigarette smoking induces apoptosis in rat testis. J Environ Pathol Toxicol Oncol. 2002;21:243-8.

59. Kapawa A, Giannakis D, Tsoukanelis K, Kanakas N, Baltogiannis D, Agapitos E, Loutradis D, Miyagawa I, Sofikitis N. Effects of paternal cigarette smoking on testicular function, sperm fertilizing capacity, embryonic development, and blastocyst capacity for implantation in rats. Andrologia. 2004;36:57-68.

60. Ahmadnia H, Ghanbari M, Moradi MR, Khaje-Dalouee M. Effect of cigarette smoke on spermatogenesis in rats. Urol J. 2007;4:159-63.

61. Sepaniak S, Forges T, Gerard H, Foliguet B, Bene MC, Monnier-Barbarino P. The influence of cigarette smoking on human sperm quality and DNA fragmentation. Toxicology. 2006;223:54-60.

62. Aoki VW, Emery BR, Liu L, Griffin J, Carrell DT. Protamine levels vary between individual sperm cells of infertile human males and correlate with viability and DNA integrity. J Androl. 2006;27:890-8.

63. Velando A, Torres R, Alonso-Alvarez C. Avoiding bad genes: oxidatively damaged DNA in germ line and mate choice. Bioessays. 2008;30:1212-9.

64. Viloria T, Meseguer M, Conejero JAM, O'Connor JE, Remohi J, Pellicer A, Garrido N. Cigarette smoking affects specific sperm oxidative defenses but does not cause oxidative DNA damage in infertile men. Fertil Steril. 2010;94:631-7.

65. Hammadeh ME, Hamad MF, Montenarh M, Fischer-Hammadeh C. Protamine contents and P1/P2 ratio in human spermatozoa from smokers and non-smokers. Hum Reprod. 2010;25:2708-20.

66. Potts JM, Pasqualotto FF. Seminal oxidative stress in patients with chronic prostatitis. Andrologia. 2003;35:304-8.

67. Tortolero I, Duarte Ojeda JM, Pamplona Casamayor M, Alvarez Gonzalez E, Arata-Bellabarba G, Regadera J, et al. The effect of seminal leukocytes on semen quality in subfertile males with and without varicocele. Arch Esp Urol. 2004;57:921-8.

68. Everaert K, Mahmoud A, Depuydt C, Maeyaert M, Comhaire F. Chronic prostatitis and male accessory gland infection—is there an impact on male infertility (diagnosis and therapy)? Andrologia. 2003;35:325-30.

69. Mostafa T, Tawadrous G, Roaia MM, Amer MK, Kader RA, Aziz A. Effect of smoling on seminal plasma ascorbic acid in infertile and fertile males. Andrologia. 2006;38(6):221-4.

70. Eshai MF, El-Sayed IH, Elsaied MA, El-Masry SA, Kumosani TA. Sperm head defects and disturbances in spermatozoal chromatin and DNA integrities in idiopathic infertile subjects: association with cigarette smoking. Clin Biochem. 2009;42:589-94.

71. Xu DX, Shen HM, Zhu QX, Chua L, Wang QN, Chia SE, Ong CN. The associations among semen quality, oxidative DNA damage in human spermatozoa and concentrations of cadmium, lead and selenium in seminal plasma. Mutat Res. 2003;534:155-63.

72. Mattila JP, Sabatini K, Kinnunen PK. Oxidized phospholipids as potential novel drug targets. Biophys J. 2007;93(9):3105-12.

73. Mao J, Price DD, Mayer DJ. Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interactions. Pain. 1995;62:259-74.

74. Arner S, Rawal N, Gustafsson LL. Clinical experience of long-term treatment with epidural and intrathecal opioids—a nationwide survey. Acta Anaesthesiol Scand. 1988;32:253-9.

75. Ossipov MH, Lai J, King T, Vanderah TW, Malan Jr TP, Hruby VJ, Porreca F. Antinociceptive and nociceptive actions of opioids. J Neurobiol. 2004;61:126-48.

76. Muscoli C, Cuzzocrea S, Ndengele MM, Mollace V, Porreca F, Fabrizi F, Esposito E, Masini E, Matuschak GM, Salvemini D. Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice. J Clin Invest. 2007; 117:3530-9.

77. Jagtap P, Szabo C. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov. 2005;4:421-40.

78. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA. 1990;87:1620-4.

79. Salvemini D, Jensen MP, Riley DP, Misko TP. Therapeutic manipulations of peroxynitrite. Drug News Perspect. 1998;11:204-14.

80. Ndengele MM, Cuzzocrea S, Esposito E, Mazzon E, Di Paola R, Matuschak GM, Salvemini D. Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity. FASEB J. 2008;22(9):3154-64.

81. Muscoli C, Sacco I, Alecce W, Palma E, Nistico R, Costa N, Clementi F, Rotiroti D, Romeo F, Salvemini D, Mehta JL, Mollace V. The protective effect of superoxide dismutase mimetic M40401 on balloon injury-related neointima formation: role of the lectin-like oxidized low-density lipoprotein receptor-1. J Pharmacol Exp Ther. 2004;311:44-50.

82. Wang ZQ, Porreca F, Cuzzocrea S, Galen K, Lightfoot R, Masini E, Muscoli C, Mollace V, Ndengele M, Ischiropoulos H, Salvemini D. A newly identified role for superoxide in inflammatory pain. J Pharmacol Exp Ther. 2004;309:869-78.

83. Bezerra MM, Brain SD, Girao VC, Greenacre S, Keeble J, Rocha FA. Neutrophils-derived peroxynitrite contributes to acute hyperalgesia and cell influx in zymosan arthritis. Naunyn Schmiedebergs Arch Pharmacol. 2007;374:265-73.

84. Lee I, Kim HK, Kim JH, Chung K, Chung JM. The role of reactive oxygen species in capsai-cin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons. Pain. 2007;133:9-17.

85. Nawrot P, Jordan S, Eastwood J, Rotstein J, Hugenholz A, Feeley M. Effects of caffeine on human health. Food Addit Contam. 2003;20:1-30.

86. Azam S, Hadi N, Khan NU, Hadi SM. Antioxidant and prooxidant properties of caffeine, theobromine, and xantine. Med Sci Monit. 2003;9:BR325-30.

87. Christian MS, Brent RL. Teratogen update: evaluation of the reproductive and developmental risks of caffeine. Teratology. 2001;64:51-78.

88. Esknazi B. Caffeine during pregnancy: grounds for concern? JAMA. 1993;270:2973-4.

89. Ashihara H, Crozier A. Caffeine: a well-known but little mentioned compound in plant science. Trends Plant Sci. 2001;6:407-18.

90. Joesoef MR, Beral V, Rolfs RT, Aral SO, Cramer DW. Are caffeinated beverages risk factors for delayed conception? Lancet. 1990;335:136-7.

91. Olsen J, Overvad K, Frische G. Coffee consumption, birthweight, and reproductive failures. Epidemiology. 1991;2:370-4.

92. Pasqualotto FF, Lucon AM, Sobreiro BP, Hallak J, Pasqualotto EB, Arap S. Does caffeine intake impair semen quality and hormonal levels in a fertile population? Fertil Steril. 2003;80:S231.

93. Dlugosz L, Bracken MB. Reproductive effects of caffeine: a review and theoretical analysis. Epidemiol Rev. 1992;14:83-100.

94. Jensen TK, Henriksen TB, Hjollund NH, Sceike T, Kolstad H, Giwercman A, et al. Caffeine intake and fecundability: a follow-up study among 430 Danish couples planning their first pregnancy. Reprod Toxicol. 1998;12:289-95.

Defeat Drugs and Live Free

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