Relationship Between OS and DNA Damage in Sperm

Sperm DNA is protected from oxidative stress by two mechanisms: tight packaging of DNA through spermatogenesis and the existence of antioxidant system in semen. OS causes single and double DNA strand breaks. Furthermore, ROS could cause apoptosis by activating the cytochrome c and caspases 9 and 3 that causes more DNA single- and double-strand breaks [12]. High levels of ROS were identified as a cause of the DNA fragmentation in spermatozoa more frequently seen in infertile men [93]. It has been also shown that oral antioxidant administration can decrease DNA fragmentation in infertile men [94] .

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