Therapeutic Strategies to Decrease ROS Production in the Penis

Continued research in the area of improving erectile function in disease states is pointing to the greater importance of targeting ROS formation, rather than ROS scavenging, for the development of an effective therapeutic strategy to reduce oxi-dative damage in the penis and ED. Several pharmacological agents have been suggested to inhibit ROS production and improve erectile function through mechanisms different and beyond their primary therapeutic actions, such as PDE5 inhibitors, angiotensin-converting enzyme (ACE) inhibitors and ATj receptor antagonists, statins, and BH4. This type of therapeutic strategy falls within the first line of recommended treatment of ED. This line of intervention involves preventable lifestyle modifications (such as discontinuation of cigarette smoking, exercise and weight control, Mediterranean-style diet, and a reduction in caloric intake) and treatable noninvasive pharmacologic therapies.

The following sections summarize recent findings regarding strategies to decrease oxidative stress and improve erectile function by targeting specific ROS-generating sources in the penis.

Dealing With Erectile Dysfunction

Dealing With Erectile Dysfunction

Whether you call it erectile dysfunction, ED, impotence, or any number of slang terms, erection problems are something many men have to face during the course of their lifetimes.

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