Clinical Manifestation and Pathology

The onset of disease usually occurs within 12 to 36 hours of ingestion of food contaminated with botulinum toxin. Botulism typically presents with an array of distressing signs of motor nerve dysfunction, including double or blurred vision and difficulty with speech and swallowing. The unabated disease progresses to generalized paralysis and death from respiratory muscle involvement.

Diagnosis is confirmed by detecting botulinum toxin in the blood, feces, or wound site of the patient. Depending on the dose of toxin, untreated botulism carries a high fatality rate. Early treatment with antitoxin accompanied by respiratory assistance and other supportive intensive care may be life-saving.

The pathophysiology involves inhibition of release of the neurotransmitter substance acetylcholine at the neuromuscular junction, thus preventing the initiation of the electrical impulse needed for muscle contraction. Electromyography shows a characteris tic decrease in amplitude of the evoked muscle action potential in response to an electrical stimulus.

Infant botulism, a condition confined to babies between 2 weeks and 9 months of age, typically presents with listlessness and generalized weakness ("floppy baby") and has been shown to cause some cases of sudden infant death syndrome (SIDS). It has been associated with ingestion of various processed infant foods - honey in particular - that contain botulinum spores. First described in the United States in 1976, where the majority of cases have been reported, infant botulism has also been documented in Europe, Australia, Asia, and South America.

11 Habits To Make or Break For Soft Flawless Skin

11 Habits To Make or Break For Soft Flawless Skin

Habits to Break and Habits to Maintain for Dazzling Skin. As you all know, our skin is the obvious appearance of who or what we are, or perhaps would like to be. However, it is more than just a simple mask.

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