Clinical Manifestations and Pathology

The onset of symptoms generally occurs 3 to 6 days after the virus is injected into the blood. In the range of moderately severe to malignant cases, the symptoms arrive suddenly with flushed features, severe chills, high fever, intense headache, and perhaps a backache and other muscular aches and pains. Quite often there is nausea. These symptoms continue throughout a restless, agitated 2 or 3 days, after which the patient characteristically experiences a remission.

From this point forward, most patients fortunately will recover, but for others, the remission will be short-lived, jaundice may set in, hallucinations frequently will take place, and internal hemorrhaging will occur, with the victim vomiting huge quantities of black vomitus. This frequently terminal signal is confirmed by convulsions, coma, and, generally from the seventh to the tenth day of the illness, death.

Early in the course of the illness the virus sets up an infection - primarily in the liver - and multiplies to the extent that just one drop of blood contains millions of virus particles. This volume of foreign matter in the blood quickly summons an antibody response, which, if the patient recovers, remains in the blood for a lifetime to ensure that he or she never will be called upon to repeat the experience. If the patient dies, pathological findings usually reveal extensive internal damage such as cardiac enlargement and kidney congestion; hemorrhages of the stomach, duodenum, bladder, and mucous membranes; and liver necrosis.

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