Clinical Manifestations

The clinical disease consists of the usual signs and symptoms of encephalitis, and no syndrome has been elicited that is specific for Japanese B encephalitis. Within a few days to several weeks (mean of 10 days) after a bite by a mosquito carrying the virus, susceptible patients manifest fever and evidence of damage to the central nervous system, which may include meningism, delirium, drowsiness, confusion, stupor, paralyses especially of the facial muscles, and, in the most severe cases, coma and death within a few days after onset.

The cerebrospinal fluid shows the presence of a nonpyogenic infection, with increased numbers of mononuclear cells, rarely over 1,000 per cubic millimeter, and elevated protein; sugar is therefore not generally decreased and may be elevated in the spinal fluid.

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