Diagnosis and Pathology

No two myasthenic patients look alike or have the same signs and symptoms. The classical appearance is unmistakable and is usually associated with bilateral ptosis, weakness of the face, and difficulty in smiling, chewing, and talking. The clinical diagnosis is confirmed by demonstrating electrical defects in transmission at the neuromuscular junction, responsiveness to anticholinesterase drugs, or the presence of the anti-acetylcholine receptor antibody circulating in the patient's blood. The consistent pathology found in every patient is autoimmune destruction of the postsynaptic receptor, simplification of the postsynaptic membrane, widening of the synaptic gap, and reduction in the acetylcholine receptor numbers and efficiency. Thymic pathology is also present in myasthenia gravis. Approximately 80 percent of patients have germinal centers and enlarged thymus, and about 10 percent of patients have a thymic tumor, a thymoma.

Your Heart and Nutrition

Your Heart and Nutrition

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