Etiology

The popular concept that osteoarthritis is a single disease resulting from attrition of cartilage due to age and wear-and-tear is not tenable in light of modem experimental studies. Osteoarthritis can be regarded as the result of aberrations in a complex pattern of biological reactions whose failure leads to anatomic changes in joint structure and function. One or more biological feedback loops may lead to malfunction of the complex system. Biological modifiers induce variable effects, depending on the target mechanism. A recent hypothesis proposes that OA is a multifactorial metabolic inflammatory disorder in which too little cartilage and too much bone are synthesized because of impaired liver function in processing growth hormone and insulin. Hepatic dysfunction results in altered neuropeptide levels: too little insulin-like growth factor-1, which is required for cartilage growth, and too much insulin, which accelerates bony growth and osteophyte formation (Denko, Boja, and Moskowitz 1987).

Treating Rheumatoid Arthritis With Herbs Spices Roots

Treating Rheumatoid Arthritis With Herbs Spices Roots

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