The popular concept that osteoarthritis is a single disease resulting from attrition of cartilage due to age and wear-and-tear is not tenable in light of modem experimental studies. Osteoarthritis can be regarded as the result of aberrations in a complex pattern of biological reactions whose failure leads to anatomic changes in joint structure and function. One or more biological feedback loops may lead to malfunction of the complex system. Biological modifiers induce variable effects, depending on the target mechanism. A recent hypothesis proposes that OA is a multifactorial metabolic inflammatory disorder in which too little cartilage and too much bone are synthesized because of impaired liver function in processing growth hormone and insulin. Hepatic dysfunction results in altered neuropeptide levels: too little insulin-like growth factor-1, which is required for cartilage growth, and too much insulin, which accelerates bony growth and osteophyte formation (Denko, Boja, and Moskowitz 1987).

Arthritis Relief and Prevention

Arthritis Relief and Prevention

This report may be oh so welcome especially if theres no doctor in the house Take Charge of Your Arthritis Now in less than 5-Minutes the time it takes to make an appointment with your healthcare provider Could you use some help understanding arthritis Maybe a little gentle, bedside manner in your battle for joint pain relief would be great Well, even if you are not sure if arthritis is the issue with you or your friend or loved one.

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