Immunology

There appears to be no significant natural resistance to infection by yaws or other pathogenic treponemes. However, there is clear evidence that some individuals can develop specific resistance or immunity following infection with these treponemes. Thus, early clinical lesions can disappear, so there can be an asymptomatic or latent period, and this may or may not be followed by later-stage symptoms. The plasma cells and lymphocytes present in treponemal lesions indicate local antibody formation and some degree of immunologic response. Sera from yaws and the other pathogenic treponemes react to the same antigens.

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