Most of the information on the early stages of the disease has been gained from studies in the mouse. Pathological features of fatal human cases have generally been consistent with the experimental findings. Early in the disease, focal hemorrhages, congestion, and edema are found in the brain. Microscopically widespread damage to Purkinje cells of the cerebellum is noted, with pervascular inflammation and multiple foci of degeneration and necrosis. Extraneural evidence of spread of the virus is found in the form of hyperplasia of the germinal centers of the lymph nodes and of the spleen; multiple foci of round-cell infiltration in many organs, including the heart, kidneys, and lungs; and, in pregnancy, infiltration of the placenta with corresponding abortion and stillbirth. Multiple lesions in the offspring indicate cross-placental passage of the virus.

Your Heart and Nutrition

Your Heart and Nutrition

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