Discover The Secret Of Immortality

Discover The Secret Of Immotality

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Discover The Secret Of Immotality Summary


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Detection of Telomerase by In Situ Hybridization and by Polymerase Chain Reaction Based Telomerase Activity Assay

Rare instances, immortalize, and this immortalization event is almost always concomitant with activation of telomerase activity (2). Telomerase is necessary for the continued proliferation of immortal and tumor cells, as inhibition results in reprogramming of the cellular senescence program (12). Telomerase activation requires a significant increase in the expression of the integral RNA component (hTR) and the activation of the catalytic subunit (hTERT). Thus, determination of telomerase activity in human cancer can be accomplished by detecting either the upregulation of hTR or activity using a polymerase chain reaction (PCR)-based assay. In this chapter, we describe both the in situ hybridization technique and the PCR-based telomeric repeat amplification protocol (TRAP) assay.

And Early Christian Worlds

In contrast to the Pythagoreans and to Plato, who believed in personal immortality, the Stoa believed in natural personal dissolution without afterlife and without Heaven or Hell. The purpose of life was to be fulfilled on Earth. The Stoa strove for phronesis, or practical wisdom how to craft and lead an honorable and a good life. The belief in the unity of all rational beings and in the fundamental equality of all men is central to Stoic and Epicurean beliefs. Panaetius (190-109 BCE), as later represented by Cicero in On Duties, speaks about professional ethics. On Duties became the manual of all later humanism, ancient and Christian, secular and religious alike. 7

Settling in Pondicherry

The relative place of the Supermind in the Vedic hierarchy of different layers of conscious existence can however more easily be indicated. It is conceived as a link-layer between the upper hemisphere of sachchidananda (the unity of divine existence, consciousness, and bliss) and the lower hemisphere of matter, life, and mind. It is described as a world where there is already differentiation into form and function, but no diminution yet of the Divine omniscience and omnipotence. In other words, it is the only type of consciousness in which perfect harmony, knowledge, light, freedom, and immortality are in principle compatible with some form of individual existence. The Vedic Rishis knew about this type of consciousness, and strived to reach it, but considered it incompatible with life in the ordinary physical world. They described the Overmind, just below it, as a 'golden lid,' a layer so light and blissful that nobody could pass through it and return. Sri Aurobindo felt however that...

Limitations of Motivational Explanation

The individual docs actually carry on a iwofold existence one to serve his own purposes and the other as a link in a chain, which he serves against his will or at least involuntarily. The individual himself regards sexuality as one of his ends whereas from another point of view he is an appendage to his germ plasm at whose disposal he puts his energies in return for a bonus of pleasure. He is the mortal vehicle of a Ipossi-bly) immortal substance like the inheritor of an entailed property who is only the temporary holder of an estate which survives him. (Freud 1914, p. 7iS)

Philosophical perspective

Philosophical issues are always a part of a grief experience. How an individual lived and previously interacted with his or her world no longer makes sense. Numerous questions about the meaning of one's existence emerge. Attention to the category of loss of some aspect of self is important here. How much of the invested self that has been lost because of this event is a pivotal issue in rebuilding Is this individual willing and capable to look within and find new dimensions of self This question becomes the foundation of ongoing assessment and subsequent intervention strategies. Moreover, loss of some aspect of self also brings attention to the fact that death becomes personalized and real for the survivors. One can no longer hide behind the cloak of immortality.

Age Curves Typical Creative Trajectory Patterns

In his landmark study, Dean Keith Simonton statistically analyzed creative trajectories of a large number of creators in varied domains, finding predictable age curves for periods of high productivity and greatest contributions. These trajectories varied by discipline and onset time of the career, but most creators peaked in terms of greatest productivity and accomplishments about 20 years after starting their training (typically late 30s or early 40s). However, Simonton clarified that because the figures are averaged, no creative person is forced to have his or her career follow the exact same course. In a different study, he also noted that especially in some domains such as music, a swan song phenomenon is often observed, with late peaks. On the other hand, Laura Tahir and Howard Gruber suggested that such approaches oversimplify creative trajectories. They noted that since every creative achievement is unique and varies by task and individual over the lifespan, there is no average...

What happens when the cell undergoes malignant changes

Research involving cells in culture has suggested that normal cells can undergo only 60-70 replications, after which time they stop growing and die. Cancer cells have, however, acquired the capability to replicate endlessly, in many cases as a result of an enzyme known as telomerase. At the end of chromosomes are telomeres, which are composed of several thousand repeats of base-pairs. During each normal cell replication the telomeres shorten until they can no longer protect the chromosomal DNA, and subsequently the cell dies. However, if telomerase is upregulated, the telomeres will be maintained above a critical length, making the cells immortal.

Personality Building Emotional Connections

And ceramics or glass They have a long tradition think of Greek pottery and Roman glass. They accept almost any color this and their total resistance to scratching, abrasion, discoloration and corrosion gives them a certain immortality, threatened only by their brittleness. They are - or were - the materials of great craft-based industries Venetian glass, Meissen porcelain, Wedgwood pottery, valued, sometimes, as highly as silver. And ceramic today has an additional association - that of advanced technology kitchen stove-tops, high pressure high temperature valves, space shuttle tiles. materials for extreme conditions.

The Human Genome Diversity Project

The HGDP requires that between 400 and 500 ethnic groups, or ''populations'' should be identified to represent humanity. Preferential treatment would be given to those populations that conformed to one or more of six criteria, ranging from those with the best knowledge of processes that impact on their genetic composition, through those populations that might be most useful in identifying specific genetic diseases, to those that are in danger of losing their genetic, cultural, or linguistic uniqueness. This last criteria means that a great number of indigenous populations are suitable for sampling in the HGDP, and this has raised a number of ethical problems (see below). There are three types of sampling that will be carried out on the populations identified. A large number of genetic markers (150) from single individuals or a smaller number from between 20 and 25 individuals. In both cases they will denote blood that will then be transformed into ''immortal'' cell lines that will...

The Sacralization And Ritualization Of Consumption

The state of grace has become one in which the disciple moves up or forward. Salvation and immortality take on earthly meanings in terms of market success and visible signs of wealth. In particular, Christianity has opened itself to capitalistic frameworks that can atone for, and respond to, the rapacious dispositions of the modern consumer. Its traditional teachings have been amended in order to tolerate consumer themes, and to inject materialistic zealousness with an aura of piety.28 Narcissistic cultural themes have clashed seriously with Christian love-of-other dictates, causing revisions wherein essentially self-interested followers can remain holy as long as they do not consciously hurt others in the course of their self-serving pursuits.

Early Days Rationale to Target the EGFR

In several cancers including non-small-cell lung cancer (NSCLC), and tumors of the prostate, breast, stomach, colon, ovary, and head and neck, further supporting their role in tumorigenesis (17, 20, 21). It is estimated that between 40 percent and 80 percent of NSCLC over-express EGFR, and 20 to 30 percent over-express HER2 (22-24). The pivotal role that the EGFR plays as a sensor of the extracellular environment and the maintenance of cellular homeostasis makes it an a priori ideal candidate for a cell in transformation to exploit in order to acquire advantageous features such as freedom of movement, nutrient independence, and immortality. The EGFR was proposed as a rational target for drug development more than 20 years ago (25, 26).

Applications In Bioethics

One response is to claim that there is crucial difference between the destruction of pathogens and the destruction of innocent human life. Even if the decision to terminate a human life is motivated by compassion, that does not, on a view widely endorsed by many religious authorities, alter the character of the act as an act of killing. Abortion involves the destruction of a being with an immortal soul, and such an act presumes on the prerogatives of the deity. This objection to abortion may also be extended as an objection to prenatal genetic testing, since a major motivation of prenatal testing is to detect genetic defects with a view to therapeutic abortion if genetic mishap is detected. Making sense of the relationship between soul and body is notoriously problematic. But even if it is granted that fetuses have immortal souls it is hard to understand how the destruction of a fetus with genes, for example, for Tay-Sachs disease or Lesch-Nyham syndrome is anything but an act of...

Illness as a Grieving Process

Physical illness may involve loss in the following areas independence, sense of control, privacy, body image healthy self, relationships, roles inside and outside the family, self-confidence, self-esteem, productivity, self-fulfillment, future plans, fantasies of immortality, hindered movement, familiar daily routines, uninterrupted sleep, ways of expressing sexuality, and pain-free existence (Lewis 1998). Many of the assumptions of the child's daily life, including the sense of future, can be shattered by the diagnosis of an illness. Youngsters may experience overwhelming threats and fears including threats to narcissistic integrity and self-esteem, regressive fear of strangers on whom the patient must rely, separation anxiety, fears of loss of love and approval, fear of loss of control of bodily functions, and fear of pain and humiliation, as well as guilt and the fear of retaliation reflecting the unconscious belief that illness may be a punishment for past behavior (Lip-sitt 1996...

The attribution of biological evolution to god is a sophisticated form of schizodoxia

One of the few outstanding scientists known for not believing in natural evolution is Dr. Francis S. Collins, whom President Obama appointed as Director of the National Institute of Health. Dr. Collins believes that evolution was actually the work of God, and he wrote a very ingenious and entertaining book in which he attributed the human changes in DNA to the hand of God 12 , even though he does not present any evidence for God's existence. It would have been more reassuring to have solid and unmistakable evidence that we were created by a God who gave us an immortal soul and eternal life, as described in the Scriptures. Echoing what Miguel de Unamuno said, I would not mind having a soul.

The Research Response

The sheer magnitude of this biomedical problem has prompted considerable research to understand normal cardiovascular biology, to discover causes of cardiovascular pathology, and to define evidence-based therapy. Yet despite vast numbers of cardiovascular studies and publications over the past century, 2002 heralded the first-ever Cold Spring Harbor Symposium on heart and vessels. Why has it taken 60 years Undoubtedly the answers to this question are many, but we suspect the root answer has to do with much of the past orientation of cardiovascular science. Unlike immunology, oncology, and neurobiology, biomedical disciplines that have each been the subject of multiple Cold Spring Harbor Symposia, until recently cardiovascular science has been firmly grounded in pathophysiologic studies, not molecular biology. Although multiple reasons likely account for the organ-based, integrative focus of cardiovascular research over the past half-century, the absence of immortalized cell lines has...

Copper Silver and Gold

Toxic Groups Drug Design

Gold has been applied in certain contexts during history. The ancient Chinese, several thousand years ago produced an elixir containing colloidal gold, which should ensure eternal life. The benefit of this treatment, however, has never been fully documented. Nevertheless, gold(I) compounds are currently the only class of drugs known to halt the progression of rheumatoid arthritis. Initially, gold compounds like gold sulfide and gold thiomalate were painfully administered as intramuscular injections. Later it was discovered that the triethylphosphinegold(I) tetra-O-acetylthioglucose (auranofin, Figure 10.15) was equally effective and could be administered orally.

Regulators of Invasion

Stromal cells have been recognized as having an active role in both the progression and inhibition of malignant invasion. Stromal cells secrete a variety of proteases, and cancer cells may stimulate them to synthesize MMPs in a paracrine fashion by releasing growth factors and human extracellular matrix metalloproteinase inducer (EMMPRIN76). Coculture with activated stromal cells can confer a malignant phenotype on immortal cells that generally display benign behavior.77'78 On the other hand, tumor stroma has in many cases been found to harbor large quantities of protease inhibitors,79 suggesting that normal fibroblasts may mount an adaptive tumoristatic response.

Michael Milkens Prostate Cancer Foundation

Cancer is a harsher teacher than inspirational bestsellers or ads for vitamin-mineral supplements. It reminds us that we are not immortal, that our time is limited, that disease and death are still out there waiting for us. . . . Cancer is the worm in the apple of jaunty optimism about life the banana peel on which even the healthiest and fittest of us slips a great teacher, if you're lucky enough to survive the lesson.

The Cancer Counselling Center of Ohio

Counselling for the dying involves a reinstatement of harmony of body, mind, spirit, and emotion. In the final stages of dying, the mind cognitively accepts the likelihood or inevitability of death the emotions have resolved quarrels and guilts with other people living or dead, and have moved beyond the anger of perhaps being cheated of a more productive life the spirit has accepted whatever sense of immortality or nothingness, welcome or anonymity that may come after death and the body prepares itself for dying, perhaps even by ceasing to fight with its own resources any longer.

Cancer as a genetic disease

Cancer-causing mutations generally affect genes that regulate cellular growth (the cell cycle) or death (apoptosis). It is thought that this process involves up to six essential alterations in cell physiology, including self-sufficiency in the production of positive growth signals disregard of inhibitory growth signals an acquired capability for sustained growth (immortality of the cell) angiogene-sis (blood vessel development) and finally metastasis (invasion and spread). Each of these changes represents the breaching of one of the body's anti-cancer mechanisms. These are predominantly somatic events, although in many of the inherited cancer syndromes one of these events may be inherited. Mutagenic environmental factors such as diet, radiation and exposure to carcinogenic compounds (e.g. cigarette smoke) can also affect the probability of these mutational events (Jorde et al., 2000).


To utilize your own inner strength in dealing with prostate cancer, men must wrestle with four ''i's'' the myth of immortality, accepting immodesty, the fear of incontinence, and the fear of impotence. Those who successfully confront these demons will find the going much easier. Those who fail to do so will be plagued by a fifth ''i'' indecision. They will also be prone to denial and depression. The latter can become a major problem a study in Florida reported that suicide among men with prostate cancer was four times more common than among all men in their same age group.1 The myth of one's own immortality confronts everyone with cancer, not just men with prostate cancer. It is the realization, usually for the first time, that ''mortal'' has two meanings a human being, and one who is subject to death. Before being diagnosed with cancer or another potentially fatal disease, we secretly believe that we are amaranths the diagnosis of cancer rapidly wilts our petals, and death becomes...

Beyond Psychology

From 1937 until 1939 Rank worked on a draft, in English, of what was to be his final book, Beyond Psychology. As suggested by the title, at this point in his life, Rank was advocating an alternative to what he considered the overly rational and reductive attempt to explain human behavior scientifically, the tendency to 'psychologize.' He returned to several of the themes he had dealt with previously neurosis is not the result of societal inhibitions or repression of impulses, but the attempt by the neurotic to exert excessive control over his own nature Rank called this 'willing the spontaneous.' Returning to a recurrent theme in his work, he saw the double as representing first the shadow or identical self, next the person with his or her past, and finally the immortal self. Again contrasting his 'constructive' experiential therapy with psychoanalysis, he regarded the

Brain repair

Advances in medical technology mean that components of the body can now be repaired or replaced by machines, transplants or enhanced healing processes. Improvements in living conditions, lifestyle and health care mean that more and more people are living longer and longer. As parts fail or wear out, things that would have previously meant disability or death no longer do for many people. The limiting factor for meaningful immortality will soon be failure of the brain and nervous system. If we could prevent or repair such failure, or circumvent it in other ways, long, high-quality life would be possible. This does not necessarily mean it would be desirable but the ethical implications of that would provide material for a whole book on their own.

Setting the Stage

Far removed from prehistoric times, modern man's battle with SOD continues. Technologies, for instance, involving biochemistry, bio-engineered clones and stem cells, highspeed computation and artificial intelligence promise healthy, extended lives. Yet, regardless of the tremendous progress in science, Nature's greatest mysteries remain an enigma. Entropy is unabated and immortality's out of reach. Philosophy, the study of truth, has been unable to resolve a single fundamental question and man's spiritual inclinations stand firm against the alluring explanatory powers of physicalism and materialism. The forces that motivate creativity and spirituality are still an open question. The purpose of this article is twofold (a) to shed light on the ancient, profound relationship between two equally essential phenomena, creativity and spirituality and (b) to open that relationship to future scientific scrutiny. Empirical investigation into the relationship between these two constructs is rare...

Search for Freedom

Rollo May, in The Courage to Create, declared Creativity is a yearning for immortality (Rollo May, 1975 31). This idea connects creativity with man's deep spiritual longing to transcend SOD, to find meaning. In 2003, Swami Shantananda, in The Splendor of Recognition, a treatise on the Kashmir Shaivite text Pratybhijna-hrdayam, described the three psychological veils that limit perceptions of reality. They are the senses of imperfection (anava-mala), separateness (mayiya-mala) and doership (karma-mala). The sense of imperfection perceives SOD as a limitation of human will that is, humans feel powerless to eradicate SOD. The pain of imperfection instills the longing to find perfect joy. Separateness discerns differences such as noise versus information, one idea exceeds another, and life is distinct from death. The pain of separateness creates a longing for union, for wholeness. Doership supports the belief that an action's effects are caused solely by the one performing the action....

Antibody Structure

Monoclonal antibodies are homogeneous antibodies with the same antigenic specificity. These antibodies are produced by a hybridoma, which is a group of identical cells termed a clone. These clones are manufactured by fusing normal lymphocytes with myeloma cells the clone keeps its normal antibody functions and receptors of lymphocytes but has the immortal growth characteristics of myeloma cells. Monoclonal antibodies provide an indefinite supply of antibody with a highly defined antigenic specificity.

The Artistic Ideal

The artist also struggles with the existential reality of limitation the limitations inherent in the medium, the artist's own limited technical skill, and the limitations of time and energy in each person's life. The artist whose work is perpetually in process and unfinished is denying the real limitation that death imposes on life that is to say none of us lives forever each of us is mortal. For Rank the will at its highest stage is a creative urge to go beyond even the final limitation of death by immortalizing oneself in creative works. Artists who come to terms with both personal limitations and the limitations of the external world need not despair instead, they can attempt to make a mark on life for all time, and in this way transcend death. Artists, according to Rank, make voluntary sacrifices. They invest their time and energy in creative pursuits, forgoing other pleasures and desires they live life fully without attempting to cheat or bribe death. Their creative work is...

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