Gelatin, similar to collagen and cellulose, initiates the intrinsic pathway of the clotting cascade through contact activation. Gelfoam and Surgifoamr are the two available bovine-derived gelatin products (Table 1). Generally, neither product is utilized alone but rather is combined with thrombin (see the section entitled "Thrombin and Gelatin").

Furthermore, gelatin will only enhance hemostasis if the clotting pathway is functional and if all the clotting factors are present.

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