Hemostasis is achieved with the production of a fibrin clot that seals a site of injury, or a damaged blood vessel.

The hemostatic process depends upon the integrated activity of vascular, platelet, and plasma factors in combination with the regulatory mechanisms of anticoagulation, which are necessary to stabilize the fibrin clot and prevent accumulation of platelets and fibrin in areas of noninjury.

More specifically, the coagulation cascade can be activated by exposure of blood to foreign surfaces, tissue factors, or by platelet activation.

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