Imaging And Labeling With Nanostructured Materials

Body or organ imaging and labeling with nanostructure materials are also being used for adjuncts to uroradiological diagnosis.

Recently, Harisinghani et al. (11) have demonstrated that highly lymphotropic super-paramagnetic nanoparticles, which gain access to lymph nodes by means of interstitial lymphatic fluid transport, allow the high-resolution magnetic resonance imaging of clinically occult lymph node metastases in patients with prostate cancer, which previously have not been detectable by any other non-invasive approach.

Using nanocantilevers, which are flexible beams, resembling a row of diving boards that can be coated with molecules, capable of binding to biomarkers, Wu et al. (12) demonstrated the quantification of prostate-specific antigen at clinically significant concentrations. In addition, a novel reagent for low-level detection in immunoadsor-bent assays has been described by Grubisha et al. (13). The reagent consists of gold nanoparticles modified to integrate bioselective species, such as antibodies, with molecular labels for the generation of intense, biolyte-selective surface-enhanced Raman scattering responses in immunoassays and other bioanalytical applications. In this study they demonstrated free prostate-specific antigen levels of approximately 1 pg/mL in human serum. It has to be appreciated that current research in its infancy at present, and the specificities and sensitivities of such methodology do not yet offer substantial advantages over conventional detection methods. However, it is inevitable that imaging and labeling with nanostructures will be clinically useful in the future in uro-oncol-ogy, as well as in non cancer cases (urinary tract stones).

0 0

Post a comment