Synthetic Therapeutic Devices

The attraction of providing minimally invasive therapies with high functionality is immediately appealing.

Recently, a human nephron filter has been introduced, utilizing nanotechnology, that would eventually make possible a continuously functioning, wearable or implantable artificial kidney (16).

The human nephron filter has been computer-modeled, and operating 12 hr/day, seven days/wk the human nephron filter provides the equivalent of 30 mL/min glomerular filtration rate (compared to half that amount for conventional thrice-weekly hemodialysis). Animal studies should begin in the next one to two years, and clinical trials would follow. The enhanced solute removal and wearable design should substantially improve patient outcomes and quality of life.

Smart nanosensors with communication capability and synthetic therapeutic devices to provide minimally invasive therapies will undoubtedly be developed, with particular interest in urological tissue engineering for urinary tract reconstruction (1).

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