The treatment of patients with advanced cancers of the larynx has changed dramatically over the last 2 decades. While anatomic preservation of the larynx can now be achieved in a large fraction of patients, overall survival remains unchanged. The continued optimization of multimodality treatment paradigms along with the incorporation of biological markers, novel treatment approaches, novel chemotherapeutic agents and innovative biologic and gene transfer techniques will hopefully further increase our ability to improve survival in these patients.
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