Genetic Factors

Genetic factors increase the risk of eating disorders. Family aggregate studies demonstrate that anorexia nervosa is familial (Lilenfeld et al. 1998; Strober et al. 2000), with genetic contributions accounting for greater than 50% of the heritable risk (Bulik 2004; Bulik et al. 2006). The basis for increased herita-bility risk in anorexia nervosa appears related to a harm-avoidant temperament and anxiety (Wagner et al. 2006). Familial aggregation of dietary disinhibition has demonstrated that mothers' dietary disinhibition predicted their daughters' disinhibition as well as being overweight (Cutting et al. 1999). Bouchard et al. (2004), using a genome-wide scan of 471 marks spanning 22 autosomes in a study of 660 adults, identified four quantitative trait loci for disinhibition and susceptibility to hunger. Future genetic studies may help to specify genetic risks, although the role of findings from such studies in informing treatment remains unclear.

Losing Weight Without Starving

Losing Weight Without Starving

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