Medical Overview

When pediatric AIDS was first described in the early 1980s, neurodevelopmental abnormalities were identified as a complication of HIV infection in children (Belman et al. 1985; Epstein et al. 1985, 1986). Over the past two decades, there has been significant improvement in morbidity and mortality due to early diagnosis of HIV-infected infants and children and immediate initiation of treatment according to CDC guidelines with drug regimens, including the use of highly active antiretroviral therapy (HAART). As a result, infants, children, and adolescents with HIV infection are living longer, and the prevalence and natural history of neurodevelopmental and neuropsychiatric symptoms in these patients have changed and in many cases improved.

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