Among adult patients, anxiety disorders are common after experiencing a stroke, with prevalence estimates of 25%-30% (Carson et al. 2005), and often include generalized anxiety or PTSD symptoms, including intrusive revisiting of the event, as well as increased somatic preoccupation. Poststroke anxiety is typically associated with right-hemisphere lesions, whereas symptoms of depression are correlated with left-hemisphere lesions (Epstein and Hicks 2005). Although 10% of children with sickle cell disease experience a stroke before age 20, placing them at greater risk for neurocognitive difficulties (Helps et al. 2003; Lemanek et al. 2003), little is known about pediatric poststroke symptoms of anxiety. A dysregulation of affect, including symptoms of anxiety, has been reported for both adults and children who experience lesions in the "limbic cerebellum" (vermis and fastigial nucleus) that can result from stroke or other conditions (Schmah-mann et al. 2007).
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