Psychosocial Adjustment

Children with TSC are at risk for a wide range of psychiatric disorders including anxiety, depression, and disruptive behavioral disorders frequently characterized by temper tantrums and aggression. Mood disorders may initially present with changes in sleep patterns, escalating aggression, or progressive social withdrawal with evidence of extreme shyness. These patients may also be prone to self-injurious behaviors (De Vries et al. 2007). Patients also experience sleep continuity disorders and a variety of specific fears and phobias. TSC is also associated with autism spectrum disorders at rates that are higher than those of any other known genetic disorder (Bolton 2004; Hunt and Shepherd 1993). Patients with TSC are 200-1,000 times more likely to experience autism spectrum disorders than the general population. Conversely, patients with autism are 200-300 times more likely to have TSC than the general population. Although the association is not yet clear, some investigators believe that the location of the tubers may affect the psychiatric presentation. For example, Bolton and Griffiths (1997) found that tubers in the temporal or temporoparietal lobes were associated with autistic symptoms, a finding that is consistent with several case reports that support the importance of temporal lobe abnormalities in the etiology of autism (Hoon and Reiss 1992). Despite these tendencies, there remains a great deal of variability in behavioral and developmental presentations among individuals in a pattern that is similar to the physical manifestations of TSC.

Aspergers Answers Revealed

Aspergers Answers Revealed

Learn How to Help, Understand amp Cope with your Aspergers Child from a UK Chartered Educational Psychologist. Before beginning any practice relating to Aspergers it is highly recommended that you first obtain the consent and advice of a qualified health,education or social care professional.

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