Psychostimulant medications are believed to have antinociceptive properties that may be mediated by norepinephrine, serotonin, or dopamine or by endogenous opioid mechanisms. Indications for psychostimulants include reduction of drowsiness caused by narcotic medications as well as the potential to reduce the dose of narcotics without diminution of their analgesic effect. Methylphenidate and dextroamphetamine have been found to be safe and effective adjuncts to opiate analgesia and have also been used in the treatment of spasmodic torticollis, spastic colon, and headaches.

Potentiation of analgesia by sympathomimetics has been well described. Caffeine is known to increase the analgesic effects of aspirin and acetaminophen, and one study suggested that dextroamphet-amine doubled the analgesic potency of morphine (Forrest et al. 1977). The long-term use of these stimulants in pain has not been systematically evaluated. The use of these drugs should probably be limited to a therapeutic trial period of several days to determine efficacy for individual patients.

Naturally Cure Your Headaches

Naturally Cure Your Headaches

Are Headaches Taking Your Life Hostage and Preventing You From Living to Your Fullest Potential? Are you tired of being given the run around by doctors who tell you that your headaches or migraines are psychological or that they have no cause that can be treated? Are you sick of calling in sick because you woke up with a headache so bad that you can barely think or see straight?

Get My Free Ebook

Post a comment