Clinical Factors 1041

There is controversy regarding the influence of the patient's age at diagnosis and the risk of disease progression to regional lymph nodes. In patients <50 years old, the percentage of lymph node metastases is 39-58%, which is similar to the rate of 48-52% in patients >50 years old.20-22 In 1996 Lopes et al. reported significantly different 5-year survival rates among patients <40, 41-60, and >60 years old of 64.5%, 59.6%, and 38.4%, respectively (p = 0.05).23 More recently, the same group have observed significant differences in univariate analysis between patients <50 and >50 years old, namely 61% and 41%, respectively (p = 0.002).20 In contrast, Lont et al. have reported 5-year survival rates of 78% in patients <60 and 85% in those >60 years old (p = 0.28).24 Recent data have demonstrated that age is an independent predictor of overall survival (HR 2.3-95% CI 1.0-5.1), as well as the presence of lymph node metastases (HR 3.2-95% CI 1.8-5.6) and pathological stage of the primary tumor (HR 1.9 - 95% CI 1.0-3.6).25

How To Reduce Acne Scarring

How To Reduce Acne Scarring

Acne is a name that is famous in its own right, but for all of the wrong reasons. Most teenagers know, and dread, the very word, as it so prevalently wrecks havoc on their faces throughout their adolescent years.

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